"Commercial scale" refers to gram scale production of a sialic acid in a single reaction. In preferred embodiments, commercial scale refers to production of greater than about 50, 75, 80, 90 or 100, 125, 150, 175, or 200 grams. https://web3buzz.net/us20110165626a1-high-yield-production-of-sialic-acid-neu5ac-by-fermentation-google-patents-4/