WHO guidelines mandate that sterility test isolators undertake detailed revalidation at least on a yearly basis, or more often if substantial improvements or upkeep activities have happened. Glove ports are positioned ergonomically and are validated with leak/penetration tests. VHP devices are integrated with cycle parameters logged and biologic indicator https://medium.com/@tailinscitech/applications-and-benefits-of-tailin-containment-isolator-for-handling-high-potency-materials-8c66a55dbcf7